Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus
Year: 2022
Type: article
Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the production of abnormal autoantibodies and immune complexes that can affect the organ and organ systems, particularly the kidneys and the cardiovascular system. Emerging evidence suggests that dysregulated lipid metabolism, especially in key effector cells, such as T cells, B cells, and innate immune cells, exerts complex effects on the pathogenesis and progression of SLE. Beyond their important roles as membrane components and energy storage, different lipids can also modulate different cellular processes, such as proliferation, differentiation, and survival. In this review, we summarize altered lipid metabolism and the associated mechanisms involved in the pathogenesis and progression of SLE. Furthermore, we discuss the recent progress in the role of lipid metabolism as a potential therapeutic target in SLE.
Source: Frontiers in Immunology
Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing General Hospital of Nanjing Military Command, Beijing Hospital, Southeast University, Capital Medical University, Peking Union Medical College Hospital, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Nanjing Medical University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4220945748