Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis
Year: 2022
Type: article
Abstract: SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
Authors: Shuai Zhang, Ornella D. Nelson, Ian R. Price, Chengliang Zhu, Xuan Lu, Irma R. Fernandez, Robert S. Weiss, Hening Lin
Institutions: Howard Hughes Medical Institute, Cornell University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4220946400