Work

Intracellular Cholesterol Synthesis and Transport

Year: 2022

Type: review

Abstract: Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

Source: Frontiers in Cell and Developmental Biology

DOI: 10.3389/fcell.2022.819281

Authors: Qingyang Shi, Jiahuan Chen, Xiaodong Zou, Xiaochun Tang

Institutions: Jilin University, First Hospital of Jilin University

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950