Work

A randomized, crossover, placebo controlled, double-blind trial of the effects of tiotropium-olodaterol on neuromuscular performance during exercise in COPD

Year: 2022

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Bronchodilation is known to increase forced expiratory volume in 1 s (FEV1) and reduce hyperinflation in COPD. In a randomized controlled trial, we investigated whether combined inhaled long-acting β-agonist and muscarinic antagonist would alleviate maximal voluntary neuromuscular performance fatigue or enhance maximal muscle activation during cycling in patients with COPD. Despite increased FEV1, combination bronchodilator therapy did not reduce neuromuscular performance fatigue or enhance muscle activity or exercise tolerance in patients with mild-to-severe COPD.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00332.2021

Authors: Min Cao, Robert A. Calmelat, Peter Kierstead, Nicolo Carraro, William W. Stringer, Janos Porszasz, Richard Casaburi, Harry B. Rossiter

Institutions: University of California, Los Angeles, The Lundquist Institute, Capital Medical University, Beijing Chest Hospital, Harbor–UCLA Medical Center

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Boehringer Ingelheim, Office of the President, University of California, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Rehabilitation Research Resource to Enhance Clinical Trials (ReACT), Center for Male Reproductive Epigenomics, A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients, G5020867033, Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants.

OpenAlex ID: W4220962157

FWCI: 1.116

Cites: 36

Cited by: 8

Related to: 10