Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group
Year: 2022
Type: article
Abstract: The Children's Oncology Group (COG) uses Clinical Group (CG) and modified Tumor Node Metastasis (TNM) stage to classify rhabdomyosarcoma (RMS). CG is based on surgicopathologic findings and is determined after the completion of initial surgical procedure(s) but prior to chemotherapy and/or radiation therapy. The modified TNM stage is based on clinical and radiographic findings and is assigned prior to any treatment. These systems have evolved over several decades. We review the history, evolution, and rationale behind the current CG and modified TNM classification systems used by COG for RMS. Data from the seven most recently completed and reported frontline COG trials (D9602, D9802, D9803, ARST0331, ARST0431, ARST0531, ARST08P1) were analyzed, and confirm that CG and modified TNM stage remain relevant and useful for predicting prognosis in RMS. We propose updates based on recent data and discuss factors warranting future study to further optimize these classification systems.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.29644
Authors: Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Zhengya Gao, Carola A. S. Arndt, Sarah S. Donaldson, Douglas J. Harrison, Douglas S. Hawkins, Corinne M. Linardic, Leo Mascarenhas, William H. Meyer, David A. Rodeberg, Erin R. Rudzinski, Barry L. Shulkin, David O. Walterhouse, Rajkumar Venkatramani, Aaron R. Weiss
Institutions: Stanford Medicine, Stanford University, University of Florida Health, University of Florida, Mayo Clinic, Baylor College of Medicine, Seattle Children's Hospital, University of Washington, Duke University, University of Southern California, Children's Hospital of Los Angeles, University of Oklahoma Health Sciences Center, East Carolina University, St. Jude Children's Research Hospital, Northwestern University, Lurie Children's Hospital, Maine Medical Center, Maine Medical Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W4221063463