Year: 2021
Type: article
Abstract: Despite extensive efforts to increase the signal-to-noise ratio (SNR) of fMRI images for brain-wide mapping, technical advances of focal brain signal enhancement are lacking, in particular, for animal brain imaging. Emerging studies have combined fMRI with fiber optic-based optogenetics to decipher circuit-specific neuromodulation from meso to macroscales. High-resolution fMRI is needed to integrate hemodynamic responses into cross-scale functional dynamics, but the SNR remains a limiting factor given the complex implantation setup of animal brains. Here, we developed a multimodal fMRI imaging platform with an implanted inductive coil detector. This detector boosts the tSNR of MRI images, showing a 2-3-fold sensitivity gain over conventional coil configuration. In contrast to the cryoprobe or array coils with limited spaces for implanted brain interface, this setup offers a unique advantage to study brain circuit connectivity with optogenetic stimulation and can be further extended to other multimodal fMRI mapping schemes.
Source: NeuroImage
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,300
Funders: National Science Foundation, California Department of Fish and Game, European Commission, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Max-Planck-Gesellschaft, Bundesministerium für Bildung und Frauen, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Horizon 2020, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, H2020 Marie Skłodowska-Curie Actions
Awards: Characterize corpus callosum-mediated local and global inhibitory effects with novel MRI-compatible photonic crystal fiber-based multifunction probe and wireless amplified NMR detector in rat brain, G1953887145, G1986492439, G2431027696, G260613799, Resting state connectivity: Biophysical basis for and improved fMRI measurements, Bridging the cellular and microvascular anatomy and functional dynamics: Upgrade the 14T horizontal MR for rodent and ex-vivo imaging, G311232875, G3825361792, G4049258706, G410517935, Entschlüsselung der Laminar-spezifischen Verbindungen und ihrer vaskulären und neuronalen Korrelate, G434337789, G4420342495, G45362635, G546745442, Sensitivity enhancement of MRI with a Wireless Amplified NMR Detector, A multi-modal wireless oscillator array for high-resolution mapping of neurovascular coupling, Development of a Multi-Modal MRI Methodology to Map Paravascular Clearance Linked to Astrocyte Dysfunction in Fetal-Onset Hydrocephalus, Develop a multi-modal cross-scale fMRI platform with laminar-specific cellular recordings through multi-channel tapered photonic crystal fiber array, G6383642394, G6976464937, Collaborative Research: NCS-FR: Understanding the neuropeptide modulation of brain circuits by advanced nanomaterials and imaging, G7521381527, Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation, G7648775861, G7864634536, Local Neuronal Drive and Neuromodulatory Control of Activity in the Pial Neurovascular Circuit, Investigating the Thalamic Regulation of Neuro-Glio-Vascular Restoration Underlying Acute Coma Recovery with Multi-Modal fMRI in a Brainstem Coma Rodent Model
OpenAlex ID: W4221129196