Work

Differences in cell death and division rules can alter tissue rigidity and fluidization

Year: 2022

Type: article

Abstract: models of tissue dynamics. Specifically, we look at cell migration, tissue response to external stress, tissue extrusion propensity and self-organization of different cell types within the tissue, as a function of cell death and division and the rules that trigger these events. We find that not only do cell death and division events significantly alter tissue mechanics when compared to systems without these events, but that the choice of triggers driving these cell death and division events also alters the predicted tissue mechanics and overall system behavior.

Source: Soft Matter

DOI: 10.1039/d2sm00174h

Authors: Gudur Ashrith Reddy, Parag Katira

Institutions: San Diego State University, University of California San Diego

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: San Diego State University, Army Research Office

Awards: G3141641755, G5010630567, G7452299184