Year: 2022
Type: article
Abstract: Biochemical oscillations, regulating the timing of life processes, need to consume energy to achieve good performance on crucial functions, such as high accuracy of the phase period and high sensitivity to external signals. However, it is a great challenge to precisely estimate the energy dissipation in such systems. Here, based on the stochastic normal form theory, we calculate the Pearson correlation coefficient between the oscillatory amplitude and phase, and a trade-off relation between transport efficiency and phase sensitivity can then be derived, which serves as a tighter form than the estimator resulting from the conventional thermodynamic uncertainty relation. Our findings demonstrate that a more precise energy dissipation estimation can be obtained by enhancing the sensitivity of the biochemical oscillations. Moreover, the internal noise and amplitude power effects have also been discovered.
Source: The Journal of Chemical Physics
DOI: 10.1063/5.0092126
Authors: Zhiyu Cao, Zhonghuai Hou
Institution: University of Science and Technology of China
Language: English
Subfield: Statistical and Nonlinear Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4221151487