Work

Disruption of Iron Homeostasis and Mitochondrial Metabolism Are Promising Targets to Inhibit Candida auris

Year: 2022

Type: article

Abstract: and in immune phagocytes. Our findings provide insights into the metabolic requirements for C. auris growth and define the mechanisms of action of pyrvinium pamoate against C. auris, demonstrating how this compound works by inhibiting the metabolic flexibility of the pathogen. As such, our study characterizes credible avenues for new antifungal approaches against C. auris.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.00100-22

Authors: Claudia Simm, Harshini Weerasinghe, David R. Thomas, Paul F. Harrison, Hayley J. Newton, Traude H. Beilharz, Ana Traven

Institutions: Monash University, The University of Melbourne, Peter Doherty Institute

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Department of Education and Training, Australian Research Council, National Health and Medical Research Council

Awards: An investigation into metabolic competition between host and pathogen in infection, Immuno-metabolic interactions of the fungal superbug Candida auris, G264402431, G6608924292, The transcriptome dynamics that refine eukaryotic gene expression, Metabolic control of gene expression networks and microbiome interactions

OpenAlex ID: W4223434286

FWCI: 2.968

Cites: 75

Cited by: 36

Related to: 10