Work

Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System

Year: 2022

Type: review

Abstract: The central nervous system (CNS) necessitates intricately coordinated immune responses to prevent neurological disease. However, the emergence of viruses capable of entering the CNS and infecting neurons threatens this delicate balance. Our CNS is protected from foreign invaders and excess solutes by a semipermeable barrier of endothelial cells called the blood-brain barrier. Thereby, viruses have implemented several strategies to bypass this protective layer and modulate immune responses within the CNS. In this review, we outline these immune regulatory mechanisms and provide perspectives on future questions in this rapidly expanding field.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms23074018

Authors: Christine Vazquez, Kellie A. Jurado

Institution: University of Pennsylvania

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,408