Year: 2022
Type: review
Abstract: Lipids are major actors and regulators of physiological processes within the lung. Initial research has described their critical role in tissue homeostasis and in orchestrating cellular communication to allow respiration. Over the past decades, a growing body of research has also emphasized how lipids and their metabolism may be altered, contributing to the development and progression of chronic lung diseases such as pulmonary fibrosis. In this review, we first describe the current working model of the mechanisms of lung fibrogenesis before introducing lipids and their cellular metabolism. We then summarize the evidence of altered lipid homeostasis during pulmonary fibrosis, focusing on their extracellular forms. Finally, we highlight how lipid targeting may open avenues to develop therapeutic options for patients with lung fibrosis.
Source: Cells
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,068
Awards: Therapeutic SMall HSPs Inhibitors: from Acute Respiratory disTress syndrome To PROGRESSive lung fibrosis, REspiratory Science Promoted by International Research Exchanges 3, G2951504692, G3072083260, G4937468798, Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer, ISITE « BFC
OpenAlex ID: W4223535139