LINC00355 regulates p27KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer
Year: 2022
Type: article
Abstract: Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in BC yet have not been studied in LSR BC. Here, we identify 1127 lncRNAs differentially expressed in LSR BC via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors. Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC.
Source: npj Breast Cancer
Authors: Abdallah M. Eteleeb, Prasanth K. Thunuguntla, Kyla Z. Gelev, Cynthia Y. Tang, Emily B. Rozycki, Alexander Miller, Jonathan T. Lei, Reyka G. Jayasinghe, Ha X. Dang, Nicole M. White, Jorge S. Reis-Filho, Elaine R. Mardis, Matthew J. Ellis, Li Ding, Jessica M. Silva-Fisher, Christopher A. Maher
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
Funders: Avon Foundation for Women, U.S. Department of Veterans Affairs, Breast Cancer Research Foundation, Robert and Janice McNair Foundation, Cancer Prevention and Research Institute of Texas, Susan G. Komen, National Institutes of Health, Washington University School of Medicine in St. Louis, National Institute on Aging, National Cancer Institute
OpenAlex ID: W4223899241