Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. METHODS: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. RESULTS: Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. CONCLUSIONS: Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.
Source: BMC Medicine
Authors: Manon Cairat, Sabina Rinaldi, Anne-Sophie Navionis, Isabelle Romieu, Carine Biessy, Vivian Viallon, Anja Olsen, Anne Tjønneland, Agnès Fournier, Gianluca Severi, Marina Kvaskoff, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Rosario Tumino, Sabina Sieri, Chiara Grasso, Amalia Mattiello, Inger T. Gram, Karina Standahl Olsen, Antonio Agudo, Pilar Amiano Etxezarreta, Maria-Jose Sánchez, Carmen Santiuste, Aurelio Barricarte, Evelyn Monninkhof, Anouk E. Hiensch, David Muller, Melissa A. Merritt, Ruth C. Travis, Elisabete Weiderpass, Marc J. Gunter, Laure Dossus
Institutions: World Health Organization, Centre international de recherche sur le cancer, Instituto Nacional de Salud Pública, Aarhus University, Danish Cancer Society, University of Copenhagen, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, University of Florence, German Cancer Research Center, University of Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, University of Potsdam, German Institute of Human Nutrition, Associazione Iblea per la Ricerca Epidemiologica E.T.S., Fondazione IRCCS Istituto Nazionale dei Tumori, University of Turin, Federico II University Hospital, University of Naples Federico II, UiT The Arctic University of Norway, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Basque Government, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Instituto Murciano de Investigación Biosanitaria, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Utrecht University, University Medical Center Utrecht, Imperial College London, University of Hawaii Cancer Center, University of Oxford
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Funders: World Health Organization, Deutsches Krebsforschungszentrum, European Association of Social Psychology, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, University of Oxford, Institut National de la Santé et de la Recherche Médicale, Universiteit Utrecht, Bundesministerium für Bildung und Forschung, Cancerfonden, Eusko Jaurlaritza, Ligue Contre le Cancer, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut National Du Cancer, Universidad de Granada, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, National Cancer Institute
Awards: G1055973116, G1192877484, G1265254713, G1437520050, G1478484880, G1767199718, G1993546569, G2027148636, G2131326840, G2235605558, G2372467518, G2409987178, G2539064604, G2572521044, G2742323354, G29072894, G2933204024, G3077395769, G3189789075, G3216658785, G3328679326, G3544161537, G3559985945, G3747421453, G375319704, G382879149, G4079049029, G4089957676, G4187108342, G4213141252, G4303038735, G4378152838, Health of vegetarians, G459595259, G4844208673, G4879533352, G490534113, G493358262, G4968824801, G5004963360, G5271742736, G558017500, G5763196120, G5783272435, G5851461211, G5897142711, G5990830295, G6022976577, G6085534252, G6442500046, G6486574503, G6766485657, G6811539369, G6923329853, G7426181285, G7447125227, G7503396464, G7597388277, G7646326732, G7677770324, G7908684568, G7987655622, G8050896463, G8147327976, G8164184896, G8279237360, G8377080268, G8480575570, G8542687542, G8702800630, G8846336397, G8959392569, G8978728421, G9000040826, G9000332718
OpenAlex ID: W4223919644