Work

The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue

Year: 2022

Type: article

Abstract: Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer.

Source: npj Breast Cancer

DOI: 10.1038/s41523-022-00410-4

Authors: Mary E. Sehl, Jill E. Henry, Anna Maria Storniolo, Steve Horvath, Patricia A. Ganz

Institutions: University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390