Work

Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP

Year: 2022

Type: article

Abstract: Thehuman internal dosimetry of the radionuclidic impurities of samarium-153 in a new bone-seeking radiopharmaceutical, 153Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid (153Sm-DOTMP), has been estimated from preclinical data. The effective dose from the impurities in lower-specific-activity 153Sm is less than 17% of the effective dose from pure Sm-153. It has a background-equivalent radiation time for a dosage of 37 MBq/kg of less than one-half year.

Source: Applied Radiation and Isotopes

DOI: 10.1016/j.apradiso.2022.110246

Authors: Richard E. Wendt, Alan R. Ketring, R. Keith Frank, Jaime Simón

Institutions: The University of Texas MD Anderson Cancer Center, IsoTherapeutics Group (United States)

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,140