Work

Cyani HAP2 structure compared to Cyani HAP2 monomeric and trimeric structures predicted by Alphafold

Year: 2022

Type: article

Abstract: To obtain a model of the postfusion state of Cyani HAP2, we used Alphafold 2 Multimer. For validation, we first predicted a monomeric structure by Alphafold 2 ColabFold. Compared to the Cyani crystal structure, the model was remarkably accurate, contained the interim β-sheet, and had Cα atom RMSDs of 0.5 to 0.6 Å for individual D1, D2, and D3 domains over all atoms and an RMSD of 3.4 Å over all 466 residues of the prefusion state.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.6476358

Authors: Feng, Juan, Springer, Timothy A

Institution: Harvard University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4224232647

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