Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. METHODS: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3-8 months over a period of 2 years (2015-2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes. RESULTS: Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study. CONCLUSIONS: Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.
Source: Tumour Virus Research
Authors: James Riddell, Andrew F. Brouwer, Heather M. Walline, Lora P. Campredon, Rafael Meza, Marisa C. Eisenberg, Emily C. Andrus, Rachel L. Delinger, Monica L. Yost, Jodi K. McCloskey, Trey B. Thomas, Suiyuan Huang, Robert L. Ferris, Dong Moon Shin, Carole Fakhry, Thomas Ow, Daniel Li, Ashley Berlot, Thomas E. Carey, Nicolas F. Schlecht
Institutions: University of Michigan, Michigan Medicine, UPMC Hillman Cancer Center, Emory University, Winship Cancer Institute, Johns Hopkins University, Albert Einstein College of Medicine, Montefiore Medical Center, U-M Rogel Cancer Center, Roswell Park Comprehensive Cancer Center, Montefiore Einstein Comprehensive Cancer Center
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,800
Funders: Roswell Park Cancer Institute, University of Michigan, National Institutes of Health, Michigan Institute for Clinical and Health Research, Comprehensive Cancer Center, University of Michigan, National Cancer Institute, Cairo University, National Cancer Institute, National Center for Advancing Translational Sciences
Awards: G1361532266, G173028751, G1852345927, G2638674773, G2792577834, G4914835, Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal Cancer, Michigan Institute for Clinical and Health Research (MCHR), From Mechanism to Population: Modeling HPV-related Oropharyngeal Carcinogenesis, G7958222963, G8839785069, G9000074379, G9000108980, University of Michigan Rogel Cancer Center Support Grant 2023-2028, Cancer Center Support Grant, Roswell Park Cancer Center Support Grant
OpenAlex ID: W4224285073