Work

Between a rock and a hard place: Regulation of mineralization in the periodontium

Year: 2022

Type: article

Abstract: The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for dentoalveolar repair. Many unanswered questions remain regarding periodontal biology. This review will focus on recent research providing insights into one enduring mystery: the precise regulation of the hard-soft tissue borders in the periodontium which define the interfaces of the cementum-PDL-alveolar bone structure. We will focus on advances in understanding the molecular mechanisms that maintain the unmineralized PDL "between a rock and a hard place" by regulating the mineralization of cementum and alveolar bone.

Source: genesis

DOI: 10.1002/dvg.23474

Authors: Natalie L. Andras, Fatma F. Mohamed, Emily Y. Chu, Brian L. Foster

Institutions: The Ohio State University, University of Maryland, Baltimore

Language: English

Topic: dental development and anomalies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,350

Funders: National Institutes of Health, National Institute of Dental and Craniofacial Research