Comparison of selenium and deiodinase enzyme among healthy controls and hypothyroid patients
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: Selenium an essential trace element plays an important role in human growth and development. Selenoproteins are involved in thyroid hormone metabolism and recent reports suggest there is increasing prevalence of subclinical hypothyroidism when compared to hypothyroidism. Objectives: In this paper, we aimed to analyse whether the altered thyroid profile observed in subclinical hypothyroidism is due to the deficiency of selenium or due to the defect in activity of deiodinase enzyme involved in thyroid hormone metabolism. Materials and methods: The study included the patients attending the outpatient department of General Medicine of VMKV Medical College and Hospitals, Salem. The study participants were classified into 3 groups based on their thyroid profile as Group 1- Control (n=20), Group 2: Patients with Subclinical hypothyroidism (n=20), Group 3: Patients with hypothyroidism (n=20). After obtaining informed consent from the study participants, blood sample was collected for Selenium and deiodinase assay. Selenium was performed in mass spectrophotometer using whole blood and deiodinase activity was measured in serum by ELISA method. Result: Our results showed a normal but statistically significant difference in the level of selenium and activity of deiodinase 2 enzyme in subclinical hypothyroidism and hypothyroidism when compared to healthy controls.
Authors: Priya K. Dhas, G. Ramani
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4224439104