Work

T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling

Year: 2022

Type: article

Abstract: TCF7L2 is expressed by bone but it was not known whether TCF7L2 expression influenced bone development. By using a mouse model with conditional disruption of Tcf7l2 in osteoblast lineage cells, we have demonstrated for the first time, to our knowledge, that TCF7L2 plays an important role in regulating osteoblasts via a noncanonical pathway.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00035.2022

Authors: Subburaman Mohan, Chandrasekhar Kesavan

Institutions: Loma Linda University, Jerry L. Pettis Memorial VA Medical Center, VA Loma Linda Healthcare System

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institute of Arthritis and Musculoskeletal and Skin Diseases