Work

Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine

Year: 2022

Type: article

Abstract: Voltage-gated calcium (Ca v ) channels regulate a broad range of physiological processes, such as muscle contraction, synaptic signal transduction, and hormone secretion. 1 Ca v 1.3 channels belong to the L-type (L for long-lasting current) Ca v subfamily (LTCC) and display diverse tissue distributions in brain, ear, heart, and endocrine organs. 2 Of note, Ca v 1.3 channels are predominantly expressed in cochlea inner hair cells, whose normal development and synaptic transmission are crucial for proper auditory function. 3

Source: Cell Research

DOI: 10.1038/s41422-022-00663-5

Authors: Xia Yao, Shuai Gao, Nieng Yan

Institution: Princeton University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,790

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of General Medical Sciences