Work

Microbial Adaptation to Enhance Stress Tolerance

Year: 2022

Type: review

Abstract: Microbial cell factories have been widely used in the production of various chemicals. Although synthetic biology is useful in improving the cell factories, adaptation is still widely applied to enhance its complex properties. Adaptation is an important strategy for enhancing stress tolerance in microbial cell factories. Adaptation involves gradual modifications of microorganisms in a stressful environment to enhance their tolerance. During adaptation, microorganisms use different mechanisms to enhance non-preferred substrate utilization and stress tolerance, thereby improving their ability to adapt for growth and survival. In this paper, the progress on the effects of adaptation on microbial substrate utilization capacity and environmental stress tolerance are reviewed, and the mechanisms involved in enhancing microbial adaptive capacity are discussed.

Source: Frontiers in Microbiology

DOI: 10.3389/fmicb.2022.888746

Authors: Yong-Shui Tan, Ren-Kuan Zhang, Zhi-Hua Liu, Bing-Zhi Li, Ying-Jin Yuan

Institutions: Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering Tianjin

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,950

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China