Work

Redistribution of CD8 + T cell subsets in metastatic renal cell carcinoma patients treated with anti‐PD ‐1 therapy

Year: 2022

Type: article

Abstract: Renal-cell carcinoma (RCC) is responsible for the majority of tumors arising from the kidney parenchyma. Although a progressive improvement in median overall survival has been observed after the introduction of anti-PD-1 therapy, many patients do not benefit from this treatment. Therefore, we have investigated T cell dynamics to find immune modification induced by anti-PD-1 therapy. Here, we show that, after therapy, RCC patients (5 responders and 14 nonresponders) are characterized by a redistribution of different subsets across the memory T cell compartment.

Source: Cytometry Part A

DOI: 10.1002/cyto.a.24562