Work

pH-Responsive Self-Assembling Peptide-Based Biomaterials: Designs and Applications

Year: 2022

Type: review

Abstract: Stimuli-responsive peptide-based biomaterials are increasingly gaining interest for various specific and targeted treatments, including drug delivery and tissue engineering. Among all stimuli, pH can be especially useful because endogenous pH changes are often associated with abnormal microenvironments. pH-Responsive amino acids and organic linkers can be easily incorporated into peptides that self-assemble into various nanostructures. Thus, these largely biocompatible and easily tunable platforms are ideal candidates for drug release and as fibrous materials capable of mimicking the native extracellular matrix. In this review, we highlight common design motifs and mechanisms of pH-responsiveness in self-assembling peptide-based biomaterials, focusing on recent advances of these biomaterials applied in drug delivery and tissue engineering. Finally, we suggest future challenges and areas for potential development in pH-responsive self-assembling peptide-based biomaterials.

Source: ACS Applied Bio Materials

DOI: 10.1021/acsabm.2c00188

Authors: Zhao Li, Yumeng Zhu, John B. Matson

Institution: Virginia Tech

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: United States-Israel Binational Science Foundation, National Institute of General Medical Sciences, Division of Materials Research

Awards: G3030832887, G4757904897, G7523277324, G7937494128