Work

Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs

Year: 2022

Type: review

Source: Pharmacology & Therapeutics

DOI: 10.1016/j.pharmthera.2022.108162

Authors: Antje-Christine Walz, Arthur J. Van De Vyver, Li Yu, Marc R. Birtwistle, Nevan J. Krogan, Mehdi Bouhaddou

Institutions: F. Hoffmann-La Roche AG, Clemson University, Gladstone Institutes, University of California, San Francisco

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Roche, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Systematic Targeting of Oncogene Interacting Proteins to Reveal New Therapeutic Strategies, Research Center for Cancer Systems Biology: Cancer Cell Map Initiative, Mechanistic Pharmacodynamic Modeling for Drug Combination Responses

OpenAlex ID: W4212858046

FWCI: 0.256

Cites: 73

Cited by: 8

Related to: 10