Work

Hypoxia-inducible factor (HIF)-3α2 serves as an endothelial cell fate executor during chronic hypoxia

Year: 2021

Type: article

Abstract: ), a gene known to promote apoptosis. We also demonstrate that caspase 3/7 activity is elevated, supporting that the role of the HIF-3α2 isoform is to promote apoptosis. Furthermore, we provide evidence that HIF-3α2 is also expressed in seven other primary endothelial cell types, suggesting that this may be a common feature of HIF-3α2 in endothelial cells.

Source: EXCLI journal

DOI: 10.17179/excli2021-4622

Authors: Jaśkiewicz, Maciej, Moszyńska, Adrianna, Serocki, Marcin, Króliczewski, Jarosław, Bartoszewska, Sylwia, Collawn, James F., Bartoszewski, Rafal

Institutions: Gdańsk Medical University, University of Alabama at Birmingham

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Award: UAB CF Research and Translation Core Center

OpenAlex ID: W4225713775

FWCI: 2.407

Cites: 42

Cited by: 38

Related to: 10