Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.
Year: 2022
Type: article
Study design: Observational Study
Abstract: Purpose: (rs9913911) genes with POAG in a sample of the Brazilian population. Furthermore, the study aimed to evaluate the relationship between these SNVs and the need for surgical intervention in glaucoma control. Methods: A cross-sectional association study with 1,009 subjects (505 patients with POAG and 504 controls) was performed. Participants underwent a comprehensive ocular examination, including the need for surgical procedures for intraocular pressure control. Genotyping of SNVs was performed using the TaqMan genotyping assay. Results: gene required antiglaucomatous surgery more frequently than those without the AA genotype (p = 0.01). Conclusions: ) and the risk for antiglaucomatous surgery.
Source: PubMed Central
Institution: Universidade Estadual de Campinas (UNICAMP)
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4225881026