Health‐Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis
Year: 2022
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL. METHODS: Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment. RESULTS: The sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, P < 0.001), episodic and constant abdominal pain (B = 04.66, P = 0.03; B = -13.25, P < 0.001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine, and endocrine disease (F [9, 271] = 8.34, P < 0.001). Borderline and clinical levels of emotional and behavioral problems (B = -10.18, P < 0.001; B = -15.98, P < 0.001), and constant pain (B = -4.46, P < 0.001) were associated with low psychosocial HRQOL (F [9, 271] = 17.18, P < 0.001). CONCLUSIONS: Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
Authors: See Wan Tham, Fuchenchu Wang, Cheryl E. Gariepy, Gretchen A. Cress, Maisam A. Abu‐El‐Haija, Melena D. Bellin, Kate M. Ellery, Douglas S. Fishman, Tanja Gonska, Melvin B. Heyman, Tom K. Lin, Asim Maqbool, Brian A. McFerron, Veronique D. Morinville, Jaimie D. Nathan, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Uzma Shah, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E. Lowe, Aliye Uc, Tonya M. Palermo
Institutions: University of Washington, The University of Texas MD Anderson Cancer Center, Nationwide Children's Hospital, University of Iowa Stead Family Children’s Hospital, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Minnesota, Children's Hospital of Pittsburgh, Baylor College of Medicine, Texas Children's Hospital, Hospital for Sick Children, University of California, San Francisco, Children's Hospital of Philadelphia, Riley Hospital for Children, Indiana University School of Medicine, Montreal Children's Hospital, McGill University, UNSW Sydney, Sydney Children's Hospital, Stanford University, Harvard University, Massachusetts General Hospital, The University of Texas Southwestern Medical Center, Hadassah Medical Center, Children's Hospital Los Angeles, Washington University in St. Louis
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Early Pathogenesis of Cystic Fibrosis Related Diabetes, Sleep deficiency and autonomic function in pediatric chronic abdominal pain, G580564498, A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic Pancreatitis, Chronic Pancreatitis Clinical Research Consortium (CPCRC) Data Coordinating Center (CPCRC-DCC), INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies, Precision Medicine Center for Cystic Fibrosis
OpenAlex ID: W4213223002