Work

The Combined Expression of the Nonstructural Protein NS1 and the N-Terminal Half of NS2 (NS2 1-180 ) by ChAdOx1 and MVA Confers Protection against Clinical Disease in Sheep upon Bluetongue Virus Challenge

Year: 2021

Type: article

Abstract: Current BTV vaccines are effective but they do not allow to distinguish between vaccinated and infected animals (DIVA strategy) and are serotype specific. In this work we have develop a DIVA multiserotype vaccination strategy based on adenoviral (ChAdOx1) and MVA vaccine vectors, the most widely used in current phase I and II clinical trials, and the conserved nonstructural BTV proteins NS1 and NS2. This immunization strategy solves the major drawbacks of the current marketed vaccines.

Source: Journal of Virology

DOI: 10.1128/jvi.01614-21

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Eva Calvo-Pinilla, Alejandro Marín-López, Gema Lorenzo, Pedro Sánchez-Cordón, Sandra Moreno, Julio Benavides, Sarah Gilbert, Aitor Nogales, Javier Ortego

Institutions: Consejo Superior de Investigaciones Científicas, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Centro de Investigación en Sanidad Animal, Yale University, Instituto de Ganadería de Montaña, Universidad de León, University of Oxford, Jenner Institute

Language: English

Topic: Vector-Borne Animal Diseases

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, European Commission, National Institutes of Health, National Center for Advancing Translational Sciences

Awards: Understanding pathogen, livestock, environment interactions involving bluetongue virus, G434337789, Yale Clinical and Translational Science Award

OpenAlex ID: W3214136522

FWCI: 1.24

Cites: 84

Cited by: 18

Related to: 10