Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis
Year: 2022
Type: article
Study design: Observational Study
Abstract: Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.
Institutions: Liverpool School of Tropical Medicine, London School of Hygiene & Tropical Medicine, Liverpool University Hospitals NHS Foundation Trust, Africa Health Research Institute, University of KwaZulu-Natal, Vanderbilt University Medical Center, Aurum Institute, NIHR Southampton Biomedical Research Centre, University of Southampton, University College London
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,320
Funders: CRDF Global, Wellcome Trust, National Institute for Health and Care Research, British Heart Foundation, Diabetes UK, Academy of Medical Sciences, South African Medical Research Council, British Infection Association, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases, Office of International Science and Engineering
Awards: G1236082472, G2093322029, G324303525, G3997856657, Bioengineering to combat the tuberculosis pandemic, Investigating the role of lung Tissue resident memory T-cell in the immunopathology of human TB, G6038230206, Investigating the role of lung Tissue resident memory T-cell in the immunopathology of human TB, Fluoroquinolone resistance in patients with multidrug-resistant tuberculosis
OpenAlex ID: W4226143000