Work

Convergent synthesis and biological evaluation of 3-[2-(benzylidenehydrazinyl)thiazol-4-yl]-4-hydroxycoumarins

Year: 2022

Type: article

Abstract: A convenient synthesis of a small library of 4-hydroxycoumarin derivatives, containing thiazole and benzylidenehydrazine moieties has been achieved, using 2-hydroxyacetophenone and aryl-and heteroaryl aldehydes as starting materials.In vitro biological studies revealed that some of the compounds exhibited modest activities, viz.; anti-malarial (65% PLDH viability), anti-trypanosomal (52% T.b.brucei viability), antimycobacterial (Visual MIC90 5.63 M) and anti-bacterial (restricting S.aureus metabolic activity after 6 h).

Source: ARKIVOC

DOI: 10.24820/ark.5550190.p011.725