Review of: "Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery"
Year: 2021
Type: peer-review
Abstract: The contribution of local adipose tissue stem cells towards obesity related comorbidities has expanded again.Recent findings demonstrate adipose derived cytokines provide critical paracrine signals on other tissue microenvironments, including cascades that impact the programming and progression colorectal cancer (CRC).In the current results published in Nature Communications, Franco et al. 1 , used adipose stromal cells (ASCs) and CRC sphere cells (CR-CSphCs) from human patients to examine this previously unknown mechanism.Specifically, the investigators were focused on the interplay between adipose precursor cells and CRC tumor cells in patients, hence highlighting a possible opportunity for pharmacotherapies that block STAT3 and impair metastasis in CRC patients.CRC is the third most common cancer and appears to be influenced by obesity, along with several other cancer types.Over the last several decades, researchers and clinicians have been focused on understanding CRC related metastasis and the role of tumor microenvironment (TME) in CRC metastasis and associated molecular mechanism by which the TME regulates metastasis.However, mechanistic links between obesity and the programming and progression of CRC risk remained undetermined.
DOI: 10.32388/mcnpyy
Authors: Roshan Kumari, Joseph F. Pierre
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4226167545