Work

EPHB2 expression is associated with intestinal phenotype of gastric cancer and indicates better prognosis by suppressing gastric cancer migration.

Year: 2022

Type: article

Abstract: studies demonstrated that CDX2 expression increased both EPHB2 transcription and protein levels. In a large cohort of GC patients, EPHB2 positivity was observed in 39% of 704 GCs and was negatively correlated with tumor differentiation, lymphovascular invasion, and tumor-node-metastasis stages. Notably, EPHB2 positivity was associated with better overall survival, and it was an independent prognostic marker in intestinal-type GCs. Overexpression of EPHB2 in GC cell lines, MKN-28 and MKN-74, reduced migration activity by suppressing phosphorylation of focal adhesion kinase, whereas no significant difference was observed in proliferation rates. Thus, we suggest that EPHB2 acts as a tumor suppressor in GCs and can be a prognostic marker in intestinal-type GCs.

Source: PubMed

Authors: Hyesung Kim, Jae Kyung Myung, Seung Sam Paik, Hyunsung Kim, Hosub Park, Yeon Ju Kim, Seung Bum Lee, Heung Up Kim, Hyun Joo Song, In Ho Jeong, Suji Hong, Chul Min Park, Cheol Lee, Younghoon Kim, Bogun Jang

Institutions: Jeju National University Hospital, Jeju National University, Hanyang University, Korea Institute of Radiological and Medical Sciences, Seoul National University

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4226184182

FWCI: 0.673

Cites: 31

Cited by: 7

Related to: 10