Work

Establishment of PANDA - a new human pancreatic ductal adenocarcinoma cell line with 3D cell culture technology

Year: 2021

Type: article

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of malignancy with one of the worst prognoses amongst any type of cancer. Surgery is applicable only to the limited number of patients with locally resectable tumors and currently represents the only curative treatment option. Treatment with chemotherapy and radiotherapy can only extend patient survival. Despite advances in conventional therapies, the five-year survival of PDAC remained largely unchanged. New in vitro and in vivo models are therefore urgently needed to investigate this type of cancer. Here, we present the establishment and characterization of a novel pancreatic cancer cell line, isolated from a patient with PDAC. Cell line abbreviated as PANDA (PANncreatic Ductal Adenocarcinoma) was established with an optimized 3D culture protocol published previously by our group. The new cancer cell line "PANDA" represents a novel in vitro approach for PDAC cancer research and new therapy testing.

Source: Neoplasma

DOI: 10.4149/210924n1360

Authors: Romana Zahumenska, Michal Kalman, Juraj Marcinek, Sandra Mersakova, Martin Kertys, Miroslav Pindura, Blazej Palkoci, Roman Kycina, Martin Vojtko, Tomas Chromec, Hugo Maurice Dumortier, Slavomira Novakova, Barbora Mitruskova, Ivan Kapralik, Dusan Loderer, Marian Grendar, Dusan Brany, Juraj Mokry, Michael Bouvet, Mark A Valasek, Jan Janik, Lukas Plank, Ludovit Laca, Erika Halasova, Jan Strnadel

Institutions: Comenius University Bratislava, Martin University Hospital, University of California San Diego

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky, Agentúra na Podporu Výskumu a Vývoja, Vedecká Grantová Agentúra MŠVVaŠ SR a SAV, European Regional Development Fund

Awards: Vývoj nových in vitro modelov pre amyotrofickú laterálnu sklerózu a testovanie bezpečnosti neurálnych prekurzorov odvodených z ľudských indukovaných pluripotentných kmeňových buniek, G5320503032, Využitie novo vyvinutých 3D nádorových in vitro modelov pri testovaní aktivovaných nanočastíc inhibujúcich opravné mechanizmy DNA, G6458549671, G7903605888

OpenAlex ID: W3216487780

FWCI:

Cites: 18

Cited by: 3

Related to: 10