Work

Glycosuria Alters Uropathogenic Escherichia coli Global Gene Expression and Virulence

Year: 2022

Type: article

Abstract: Uropathogenic Escherichia coli (UPEC) is an important causative agent of urinary tract infections in diabetic humans. We examined the effects of in vitro exposure to glycosuria (presence of glucose in urine) on the virulence and gene expression by UPEC. Our results show that glycosuria rapidly (in 2 h) alters UPEC gene expression, induces biofilm formation, and suppresses type 1 piliation. These results offer novel insights into the pathogenesis of UPEC in the urinary tract.

Source: mSphere

DOI: 10.1128/msphere.00004-22

Authors: Md Jahirul Islam, Kamal Bagale, Preeti P. John, Zachary Kurtz, Ritwij Kulkarni

Institution: University of Louisiana at Lafayette

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500