Work

Three-dimensional optimization of scaffold porosities for bone tissue engineering

Year: 2026

Type: article

Abstract: We consider the optimal scaffold design problem associated with a previously considered, three-dimensional, time-dependent model for scaffold-mediated bone regeneration. We prove existence of optimal scaffold designs and present numerical evidence that optimized scaffolds mitigate stress shielding effects resulting from exterior fixation of the scaffold at the defect site.

Source: European Journal of Applied Mathematics

DOI: 10.1017/s0956792526100540

Authors: Patrick Dondl, Marius Zeinhofer

Institutions: University of Freiburg, University of Education Freiburg, ETH Zurich

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,550

OpenAlex ID: W4226277678

FWCI:

Cites:

Cited by: 1

Related to: 10