Connectivity Patterns Evoked by Fearful Faces Demonstrate Reduced Flexibility Across a Shared Dimension of Adolescent Anxiety and Depression
Year: 2022
Type: article
Study design: Observational Study
Abstract: Adolescents experiencing anxiety or depression exhibit cognitive biases favoring the processing of negative emotional information. It remains unknown whether common neurobiological processes underlie these biases across anxiety and depression. Here, brain imaging was acquired from typical, anxious, and depressed adolescents during an emotional interference task. Functional connectivity patterns were assessed while adolescents were cued to attend to or ignore faces. Results revealed a shared dimension of anxious and depressive symptoms was associated with reduced changes in connectivity patterns between conditions wherein adolescents needed to ignore or attend to fearful faces. These findings were exclusive to fearful faces and only observed for functional connections with a primary face-representation area (fusiform gyrus). Results suggested a failure to flexibly adapt communication patterns with sensory representation areas in the presence of negative emotional information, which may reflect a common neurobiological mechanism explaining biases favoring such information shared amongst adolescent anxiety and depression.
Source: Clinical Psychological Science
Authors: Nicholas A. Hubbard, Randy P. Auerbach, Viviana Siless, Nicole Lo, Isabelle R. Frosch, Danielle E. Clark, Robert Jones, Rebecca Kremens, Megan Pinaire, Flavia Vaz-DeSouza, Satrajit S. Ghosh, Aude Henin, Stefan G. Hofmann, Diego A. Pizzagalli, Isabelle M. Rosso, Anastasia Yendiki, Susan Whitfield-Gabrieli, John D. E. Gabrieli
Institutions: University of Nebraska–Lincoln, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Columbia University, Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, McLean Hospital, Boston University, Philipps University of Marburg, Northeastern University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Brain and Behavior Research Foundation, James S. McDonnell Foundation, Alexander von Humboldt-Stiftung, National Institutes of Health, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, National Center for Complementary and Integrative Health
Awards: 1/2-Yoga For Generalized Anxiety Disorder, G1789241521, G1947541920, G2292483043, Multimodal imaging of hippocampal-cortical networks and mechanisms of trauma-related intrusions, Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum Disorders, G3088244570, Multi level Analysis of Positive Valence Systems Across Mood Disorders, G3549961684, Connectome 2.0: Developing the next generation human MRI scanner for bridging studies of the micro-, meso- and macro-connectome, Imaging the neurodevelopmental trajectory of depression and anxiety disorders with HCP protocols, G4855150021, G5052622912, Adolescent Brain Bases of Intergenerational Risk for Depression, Computeserver Structural &Functional Image Analysis, Cerebral GABA and Fear Conditioning in PTSD, G668207740, G7398511496, G741565811, G78607090, Nipype: Dataflows for Reproducible Biomedical Research, Multimodal mapping of the neurocircuitry of the human prefrontal cortex, G824017836, Connectomes Related to Anxiety and Depression in Adolescents, A Storage Area Network for Structural and Functional Image Analysis, G9000126849, ReproNim: A Center for Reproducible Neuroimaging Computation, Neuroimaging Studies of Reward Processing in Depression, Social Processing Deficits in Remitted Adolescent Depression, Rural Drug Addiction Research (RDAR) Center - Phase 2, Silicon Graphics Prism Extreme 128P/1TB
OpenAlex ID: W4226372086