Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: Preeclampsia is characterized by an imbalance in angiogenic factor, including soluble endoglin. Serum soluble endoglin levels were significantly different in patient with preeclampsia than in healthy pregnancy.Aim of the work: Evaluation of the increased level of serum soluble endoglin in preeclampsia and normotensive pregnant females.Patients and Methods: Forty pregnant female of at least twenty weeks of gestation were included and divided into two equal groups; preeclamptic and non preeclamptic group. 5ml of blood were collected by venipuncture into test tube without anticoagulant. Plasma endoglin was assayed by one-step sandwich enzyme immunoassay using monoclonal antibodies to human endoglin using kits.Results: preeclampsia group had higher endoglin level compared to normal one with statistically highly significant difference 18.52 ± 9.54 versus 2.2 ± 1.4 (p= 0.000) and elevated serum soluble endoglin showed a significant +ve correlation (r=0.523, P=0.016) with a risk of pre-eclampsia. With the highest positive predictive and lowest negative predictive values, a cutoff point of 6.26500 ng/ml had the best sensitivity and specificity.Conclusion: Serum soluble endoglin has a remarkable accuracy for diagnosis of preeclampsia.
Source: Ain Shams Medical Journal
Authors: Samar Ibrahim, Alaa Hassanin, Helmy Elsyad, Amani Abdel Ghani, Salma Nassar
Institution: Ain Shams University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Ain Shams University
OpenAlex ID: W4229016727