Year: 2022
Type: article
Abstract: BACKGROUND: Women diagnosed with breast cancer prior to age 45 years (<45y) and within the first 5 years postpartum (postpartum breast cancer, PPBC) have the greatest risk for distal metastatic recurrence. METHODS: Pooling data from the Colorado Young Women Breast Cancer cohort and the Breast Cancer Health Disparities Study (N = 2519 cases), we examined the association of parity, age, and clinical factors with overall survival (OS) of breast cancer over 15 years of follow-up. RESULTS: Women with PPBC diagnosed at <45y had the lowest OS (p < 0.0001), while OS of nulliparous cases diagnosed at <45y did not differ from OS of cases diagnosed at 45-65y regardless of parity status. After adjustment for study site, race/ethnicity, clinical stage, year of diagnosis and stratification for oestrogen receptor status, PPBC remained an independent factor associated with poor OS. Among cases diagnosed at <45y, nulliparous cases had 1.6 times better OS (hazard ratio (HR) = 0.61, 95%CI 0.42-0.87) compared to those with PPBC, with a more pronounced survival difference among stage I breast cancers (HR = 0.30, 95%CI 0.11-0.79). Among very young women diagnosed at age ≤35y, nulliparous cases had 2.3 times better OS (HR = 0.44, 95%CI 0.23-0.84) compared to PPBC. CONCLUSION: Our results suggest that postpartum status is the main driver of poor prognosis in young women with breast cancer, with the strongest association in patients diagnosed at age ≤35y and in those with stage I disease.
Source: European Journal of Cancer
Institutions: University of Colorado Cancer Center, University of Colorado Denver, Colorado School of Public Health, University of Colorado Colorado Springs, University of Utah, University of Louisville, Oregon Health & Science University, OHSU Knight Cancer Institute, University of Colorado Anschutz, Stanford Medicine, Stanford University
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
Awards: BREAST CANCER RISK FACTORS IN HISPANIC WOMEN, G1941076184, Discovering mechanisms of sensitivity and resistance to triple combination targeted therapy in HR+/HER2+ breast cancer, G215709867, G3715749466, FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY, FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY, THE 4 CORNERS BREAST AND ENDOMETRIAL CANCER STUDY, NSAIDs During Postpartum Involution for Breast Cancer Chemoprevention, FOUR-CORNERS BREAST CANCER STUDY, G740588530, G863030375, University of Colorado Cancer Center Support Grant
OpenAlex ID: W4229034689