Coffee Consumption May Mitigate the Risk for Acute Kidney Injury: Results From the Atherosclerosis Risk in Communities Study

Year: 2022

Type: article

Abstract: Introduction Coffee is one of the most frequently consumed beverages worldwide and has been found to have a wide assortment of health benefits. Although habitual coffee consumption is associated with a lower incidence of chronic kidney disease, an association between coffee and acute kidney injury (AKI) has not yet been revealed. Methods In the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort study of 14,207 adults aged 45 to 64 years, coffee consumption (cups/d) was assessed at a single visit via food frequency questionnaires and compared with incident AKI defined by hospitalization with an AKI-related International Classification of Diseases code. Results In ARIC, there were 1694 cases of incident AKI in a median of 24 follow-up years. Higher coffee consumption was associated with lower AKI risk versus no consumption (hazard ratio [HR] <1 cup/d: 0.92 [95% CI: 0.79–1.08]; 1 cup/d: 1.08 [95% CI: 0.94–1.24]; 2 to 3 cups/d: 0.83 [95% CI: 0.72–0.95]; >3 cups/d: 0.83 [95% CI: 0.71–0.96]; reference: never, P = 0.003). Trends for AKI risk across coffee categories remained significant after multivariable adjustment for age, sex, race-center, education, total daily energy intake, physical activity, smoking, alcohol intake, diet quality (Dietary Approaches to Stop Hypertension [DASH] score), systolic blood pressure (BP), diabetes status, use of antihypertensive agents, estimated glomerular filtration rate (eGFR), and body mass index (BMI) ( P = 0.02). Conclusion Higher coffee intake was associated with a lower risk of incident AKI and could present an opportunity for cardiorenal protection through diet. Further evaluation of the physiological mechanisms underlying the cardiorenal protective effects of coffee consumption is necessary.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2022.04.091

Authors: Kalie L. Tommerdahl, Emily A. Hu, Elizabeth Selvin, Lyn M. Steffen, Josef Coresh, Morgan E. Grams, Petter Bjornstad, Casey M. Rebholz, Chirag R. Parikh

Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver, Johns Hopkins University, University of Minnesota, Johns Hopkins Medicine

Language: English

Topic: Coffee research and impacts

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,625

Funders: U.S. Department of Health and Human Services, American Heart Association, Boettcher Foundation, Children's Hospital Colorado Research Institute, Juvenile Diabetes Research Foundation United States of America, University of Colorado, Government of South Australia, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, University of Colorado School of Medicine, Anschutz Medical Campus

OpenAlex ID: W4229035985