Work

Multi-ancestry genome-wide analysis identifies effector genes and druggable pathways for coronary artery calcification

Year: 2022

Type: preprint

Abstract: Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts symptomatic coronary artery disease. Identifying genetic risk factors for CAC may point to new therapeutic avenues for preventing clinical disease. Here, we conducted a multi-ancestry genome-wide association study in 26,909 individuals of European ancestry and 8,867 individuals of African American ancestry. We identified 11 independent risk loci, of which 8 are novel for CAC. Some novel loci harbor candidate causal genes supported by multiple lines of functional evidence. Together, these findings help refine the genetic architecture of CAC, extend our understanding of the biological pathways underlying CAC formation, as well as identify druggable targets for CAC.

Source: medRxiv

DOI: 10.1101/2022.05.02.22273844

Authors: Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Christopher J. O’Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller

Institutions: Erasmus MC, Harvard University, Massachusetts General Hospital, University of Virginia, Brigham and Women's Hospital, VA Boston Healthcare System, University of Michigan, Utrecht University, University Medical Center Utrecht

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4229048652

Cites: 70

Cited by: 5

Related to: 10