Cross-calibration of two dual-energy X-ray absorptiometry devices for the measurement of body composition in young children
Year: 2022
Type: article
Abstract: This study aimed to cross-calibrate body composition measures from the GE Lunar Prodigy and GE Lunar iDXA in a cohort of young children. 28 children (mean age 3.4 years) were measured on the iDXA followed by the Prodigy. Prodigy scans were subsequently reanalysed using enCORE v17 enhanced analysis ("Prodigy enhanced"). Body composition parameters were compared across three evaluation methods (Prodigy, Prodigy enhanced, iDXA), and adjustment equations were developed. There were differences in the three evaluation methods for all body composition parameters. Body fat percentage (%BF) from the iDXA was approximately 1.5-fold greater than the Prodigy, whereas bone mineral density (BMD) was approximately 20% lower. Reanalysis of Prodigy scans with enhanced software attenuated these differences (%BF: - 5.2% [95% CI - 3.5, - 6.8]; and BMD: 1.0% [95% CI 0.0, 1.9]), although significant differences remained for all parameters except total body less head (TBLH) total mass and TBLH BMD, and some regional estimates. There were large differences between the Prodigy and iDXA, with these differences related both to scan resolution and software. Reanalysis of Prodigy scans with enhanced analysis resulted in body composition values much closer to those obtained on the iDXA, although differences remained. As manufacturers update models and software, researchers and clinicians need to be aware of the impact this may have on the longitudinal assessment of body composition, as results may not be comparable across devices and software versions.
Source: Scientific Reports
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,190
Funders: New Zealand Government, National Institute for Health and Care Research, British Heart Foundation, University of Southampton, European Commission, National Research Foundation, National University of Singapore, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, University of Auckland, National University Health System, National Institute for Health Research Southampton Biomedical Research Centre, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Medical Research Council, Erasmus+
Awards: G103267656, G1321528303, Programme 1: Musculoskeletal health in later life, G1503713314, G1659327504, G1727471521, G183778332, G1956390128, G195975639, G2125390887, G2154835441, G2400945375, G2596139817, G2693923786, G2838213439, G3015108477, Muscle resilience across the life course: from cells to society, G3236441892, G3264401604, G3424013768, NIHR Senior Investigator Award, G3521509650, G3552626036, G3567992497, G3637715992, G3772266808, G3873828540, G3883922659, G389277099, G4213458000, G427574963, G4331660922, G434559078, NIHR Senior Investigator Award, Capacity Building to Improve Early Nutrition and Health in South Africa, Programme 3: Early development and risk of adult musculoskeletal disease, G4964355645, G5023485246, G5061114777, G5068482306, G5196117068, G524590474, G5285226399, G5318721926, G5435949906, G5741042489, G606602278, G6153309438, G6206044308, G6228189793, Establishment of a National Network on Musculoskeletal Ageing, G645171559, G6476329095, Lifecourse Determinants of Bone and Joint Disease, G6556664770, G6719865625, NIHR Senior Investigator Award, G6970511888, G71336211, G7295670324, G7348633402, G7388601084, G740803340, MRC Lifecourse Epidemiology Centre - Core Support, G7485733262, G7671148335, G7841460102, G7851905008, G7852524164, G7865205193, G7915200173, G8307928819, G8385395667, Nutrition, Development and Lifelong Health: Studies in European Populations, G8537882575, G854637805, G8579916563, G8591204548, G8606453147, G8746938047, G958113871
OpenAlex ID: W4292178426