Year: 2022
Type: article
Abstract: Updated threshold dose-distribution data for sesameTo the Editor, Sesame is classified as a "major" food allergen for which mandatory disclosure is required.Understanding reaction thresholds and how these vary within the allergic population is crucial in providing appropriate dietary advice to patients, providing guidance to the food industry, and informing dosing regimens for oral food challenges (FC).However, the largest data series used to derive a threshold dose-distribution for sesame included blinded challenge data from just 40 individuals.1 Data from low-dose, open FC can be used to supplement that from blinded FC, reducing uncertainty in estimating threshold dose-distributions for allergenic foods which otherwise lack sufficient data. 2 We, therefore, undertook a systematic search of the literature and performed dose-distribution modelling of individual patient FC data (including open FC) to update estimated eliciting doses for sesame.Eleven studies were included (Table S1), representing data from 246 positive FC.The discrete and cumulative eliciting dose predicted Houben 2020 5 (n=40) 1 teaspoon of tahini 1 sesame seed 20 sesame seeds
Source: Allergy
DOI: 10.1111/all.15364
Authors: Paul J. Turner, Magdalena Gretzinger, Nandinee Patel, Helen A. Brough, R. Sharon Chinthrajah, Motohiro Ebisawa, Arnon Elizur, Jennifer J. Koplin, Rachel L. Peters, Natasha Purington, Anna Nowak‐Wegrzyn, Sarah Saf, Hugh A. Sampson, Joost Westerhout, W. Marty Blom, Joseph L. Baumert, Geert F. Houben, Benjamin C. Remington
Institutions: Imperial College London, National Health Service, King's College London, Guy's and St Thomas' NHS Foundation Trust, Evelina London Children's Healthcare, Stanford Medicine, Stanford University, National Sagamihara Hospital, Tel Aviv University, Assaf Harofeh Medical Center, The University of Melbourne, Murdoch Children's Research Institute, NYU Langone Health, University of Warmia and Mazury in Olsztyn, New York University, Hôpital Armand-Trousseau, Icahn School of Medicine at Mount Sinai, Netherlands Organisation for Applied Scientific Research, University of Nebraska–Lincoln
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
OpenAlex ID: W4229368553