“Jump Start and Gain” Model for Dosage Compensation in Drosophila Based on Direct Sequencing of Nascent Transcripts
Year: 2013
Type: article
Abstract: (Cell Reports 5, 629–636; October 31, 2013)In the originally published version of this article, the text “Jump start” in Figure 4E was cut off and illegible. Figure 4 has now been corrected online.The journal apologizes for any confusion this error may have caused. (Cell Reports 5, 629–636; October 31, 2013) In the originally published version of this article, the text “Jump start” in Figure 4E was cut off and illegible. Figure 4 has now been corrected online. The journal apologizes for any confusion this error may have caused. “Jump Start and Gain” Model for Dosage Compensation in Drosophila Based on Direct Sequencing of Nascent TranscriptsFerrari et al.Cell ReportsOctober 31, 2013In BriefDosage compensation in fruit flies occurs by increasing male X-linked transcription approximately 2-fold. Two currently debated models for dosage compensation propose that the primary mechanism is either increased promoter recruitment or facilitated elongation of RNA polymerase on male X-linked genes. Park, Kuroda, and colleagues use nascent RNA sequencing along with public datasets of GRO-seq, short 5' RNA sequencing and ChIP-seq to probe the two models. Their results support facilitated transcriptional elongation as a key mechanism for dosage compensation in Drosophila. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4229623484