Coupling Apoptosis Resistance to the Cellular Sress Response: The IAP-Hsp90 Connection in Cancer
Year: 2004
Type: article
Abstract: How tumor cells manage to survive and proliferate in ever-changing and often harmful microenvironments is a daunting challenge in tumor biology, and a major cause of treatment failure in the oncology clinic. Recent data have now demonstrated a direct link between the molecular chaperone Hsp90 and survivin, a dual regulator of cell proliferation and cell death over-expressed in virtually every human tumor. While the survivin-Hsp90 association may help tumor cells elevate their anti-apoptotic threshold and promote their proliferation, it may also provide new opportunities for rational cancer therapy.
Source: Cell Cycle
DOI: 10.4161/cc.3.3.707
Author: Dario Altieri
Institution: University of Massachusetts Chan Medical School
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4229676984