Work

Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

Year: 2002

Type: article

Abstract: Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.

Source: European Journal of Immunology

DOI: 10.1002/1521-4141(200204)32:4<945::aid-immu945>3.0.co;2-m