Work

577. Inducible Regulation of Runx2-Stimulated Osteogenesis

Year: 2006

Type: article

Abstract: Introduction Cell-based approaches to bone regeneration often use gene therapy to induce osteogenesis in non-osteoblastic cells. However, unregulated overexpression of osteogenic proteins risks aberrant effects of uncontrolled signaling, including tumorigenesis and abnormal bone formation. Additionally, the incorporation of regulation into these systems allows for studying unique patterns of gene expression, including varying duration and magnitude, cycling of expression over time, and the sequential presence of multiple exogenous genes.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.650

Authors: Charles A. Gersbach, Joseph M. Le Doux, Robert E. Guldberg, Andres J. Garcia

Institution: Georgia Institute of Technology

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500