Correction: White Matter Abnormalities and Structural Hippocampal Disconnections in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

Year: 2013

Type: erratum

Abstract: The purpose of this project was to evaluate white matter degeneration and its impact on hippocampal structural connectivity in patients with amnestic mild cognitive impairment, non-amnestic mild cognitive impairment and Alzheimer's disease.We estimated white matter fractional anisotropy, mean diffusivity and hippocampal structural connectivity in two independent cohorts.The ADNI cohort included 108 subjects [25 cognitively normal, 21 amnestic mild cognitive impairment, 47 non-amnestic mild cognitive impairment and 15 Alzheimer's disease].A second cohort included 34 subjects [15 cognitively normal and 19 amnestic mild cognitive impairment] recruited in Montreal.All subjects underwent clinical and neuropsychological assessment in addition to diffusion and T1 MRI.Individual fractional anisotropy and mean diffusivity maps were generated using FSL-DTIfit.In addition, hippocampal structural connectivity maps expressing the probability of connectivity between the hippocampus and cortex were generated using a pipeline based on FSL-probtrackX.Voxel-based group comparison statistics of fractional anisotropy, mean diffusivity and hippocampal structural connectivity were estimated using Tract-Based Spatial Statistics.The proportion of abnormal to total white matter volume was estimated using the total volume of the white matter skeleton.We found that in both cohorts, amnestic mild cognitive impairment patients had 27-29% white matter volume showing higher mean diffusivity but no significant fractional anisotropy abnormalities.No fractional anisotropy or mean diffusivity differences were observed between non-amnestic mild cognitive impairment patients and cognitively normal subjects.Alzheimer's disease patients had 66.3% of normalized white matter volume with increased mean diffusivity and 54.3% of the white matter had reduced fractional anisotropy.Reduced structural connectivity was found in the hippocampal connections to temporal, inferior parietal, posterior cingulate and frontal regions only in the Alzheimer's group.The severity of white matter degeneration appears to be higher in advanced clinical stages, supporting the construct that these abnormalities are part of the pathophysiological processes of Alzheimer's disease.

Source: PLoS ONE

DOI: 10.1371/annotation/c1e8aa6c-5e8a-4938-a0ed-1a7dc5ead757

Authors: Jared Rowley, Vladimir Fonov, Ona Wu, Simon Fristed Eskildsen, Dorothee Schoemaker, Liyong Wu, Sara Mohades, Monica Shin, Viviane Sziklas, Laksanun Cheewakriengkrai, Amir Shmuel, Alain Dagher, Serge Gauthier, Pedro Rosa-Neto, for the Alzheimer's Disease Neuroimaging Initiative

Institutions: McGill University, Montreal Neurological Institute and Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Aarhus University, Capital Medical University, Xuan Wu Hospital of the Capital Medical University

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382

Funders: Foundation for the National Institutes of Health, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Biogen, F. Hoffmann-La Roche, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Northern California Institute for Research and Education, National Natural Science Foundation of China, Eisai, National Institutes of Health, University of California, Los Angeles, University of California, San Diego, Canadian Institutes of Health Research, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering

OpenAlex ID: W4230683604