Work

Group refractive index reconstruction with broadband interferometric confocal microscopy

Year: 2008

Type: article

Abstract: We propose a novel method of measuring the group refractive index of biological tissues at the micrometer scale. The technique utilizes a broadband confocal microscope embedded into a Mach-Zehnder interferometer, with which spectral interferograms are measured as the sample is translated through the focus of the beam. The method does not require phase unwrapping and is insensitive to vibrations in the sample and reference arms. High measurement stability is achieved because a single spectral interferogram contains all the information necessary to compute the optical path delay of the beam transmitted through the sample. Included are a physical framework defining the forward problem, linear solutions to the inverse problem, and simulated images of biologically relevant phantoms.

Source: Journal of the Optical Society of America A

DOI: 10.1364/josaa.25.001156

Authors: Daniel L. Marks, Simon C. Schlachter, Adam M. Zysk, Stephen A. Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Digital Holography and Microscopy

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funders: University of Illinois at Urbana-Champaign, National Institute of Biomedical Imaging and Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign

Awards: G3342837969, G3467840974