Work

Faculty Opinions recommendation of Structure of the yeast mitochondrial large ribosomal subunit.

Year: 2014

Type: peer-review

Abstract: Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts.We have solved the structure of the yeast mitoribosomal large subunit using singleparticle electron cryo-microscopy.The resolution of 3.2 Ångstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA.The structure reveals a new exit tunnel path and architecture, unique elements of the E site and a putative membrane docking site.

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.718325834.793493241

Authors: James K Stoops, Jun Liu

Institutions: The University of Texas Health Science Center at Houston, Yale University

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Agouron Institute, Wellcome Trust, Medical Research Council

Awards: G1956668798, G2026990854, G5524861217, G6993657297, G8538723892

OpenAlex ID: W4232535743

Cites: 31

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Related to: 10